/* ============================================================
   INTERSPACE BIOSYSTEMS — TBDS Platform
   Stylesheet v4.0  |  Bold · Alive · Readable
   ============================================================ */

/* Fonts loaded via <link> tags in each HTML page for reliable file:// support */

/* ── Variables ──────────────────────────────────────────────── */
:root {
  --bg-base:    #111827;
  --bg-surface: #161d2e;
  --bg-card:    #1a2236;
  --surface:    #161d2e;   /* alias for --bg-surface */
  --bg-card2:   #1e2845;
  --bg-strip:   #0d1220;

  --red:   #e63946;
  --blue:  #4a90e2;
  --green: #27c97a;
  --amber: #f5a623;
  --gray:  #6b7280;

  --text:       #eef2f7;
  --text-dim:   #9baabb;
  --text-muted: #4a5568;

  --border:     rgba(255,255,255,0.07);
  --border-med: rgba(255,255,255,0.14);

  --nav-h:  76px;
  --max-w:  1200px;
  --r:      8px;
  --trans:  0.3s ease;
}

/* ── Reset ──────────────────────────────────────────────────── */
*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
html { scroll-behavior: smooth; font-size: 17px; }
body {
  background: var(--bg-base);
  color: var(--text);
  font-family: 'Inter', sans-serif;
  line-height: 1.7;
  -webkit-font-smoothing: antialiased;
}
img { max-width: 100%; display: block; }
a   { color: inherit; text-decoration: none; }
ul  { list-style: none; }

/* ── Typography ─────────────────────────────────────────────── */
h1,h2,h3,h4,h5 {
  font-family: 'Space Grotesk', sans-serif;
  font-weight: 700;
  line-height: 1.15;
}
.mono { font-family: 'JetBrains Mono', monospace; }

/* ── Layout ─────────────────────────────────────────────────── */
.container      { max-width: var(--max-w); margin: 0 auto; padding: 0 32px; }
.section        { padding: 88px 0; }
.section--tight { padding: 60px 0; }
.section--sm    { padding: 44px 0; }

/* ══════════════════════════════════════════════════════════════
   NAVBAR
══════════════════════════════════════════════════════════════ */
.navbar {
  position: fixed;
  top: 0; left: 0; right: 0;
  height: var(--nav-h);
  z-index: 100;
  display: flex;
  align-items: center;
  transition: background var(--trans), box-shadow var(--trans);
}
.navbar.scrolled {
  background: rgba(10,14,26,0.97);
  backdrop-filter: blur(20px);
  box-shadow: 0 1px 0 var(--border);
}
.nav-inner {
  display: flex;
  align-items: center;
  justify-content: space-between;
  width: 100%;
  max-width: var(--max-w);
  margin: 0 auto;
  padding: 0 32px;
}
.nav-logo { display: flex; align-items: center; gap: 14px; }
.nav-logo-text { display: flex; flex-direction: column; line-height: 1.1; }
.nav-logo-text .nlt-main {
  font-family: 'Space Grotesk', sans-serif;
  font-weight: 700; font-size: 0.95rem;
  letter-spacing: 0.18em; color: var(--text);
}
.nav-logo-text .nlt-sub {
  font-family: 'Space Grotesk', sans-serif;
  font-weight: 600; font-size: 0.68rem;
  letter-spacing: 0.24em;
  color: var(--green);     /* ← GREEN */
  text-transform: uppercase;
}
.nav-links { display: flex; align-items: center; gap: 4px; }
.nav-link {
  padding: 8px 15px;
  font-size: 0.9rem; font-weight: 500;
  color: var(--text-dim); border-radius: 5px;
  transition: color var(--trans), background var(--trans);
}
.nav-link:hover, .nav-link.active { color: var(--text); background: rgba(255,255,255,0.06); }
.nav-toggle { display: none; background: none; border: none; cursor: pointer; padding: 8px; color: var(--text); }

/* ══════════════════════════════════════════════════════════════
   HERO
══════════════════════════════════════════════════════════════ */
.hero {
  min-height: 100vh;
  display: flex;
  align-items: center;
  position: relative;
  overflow: hidden;
  padding-top: var(--nav-h);
  background:
    radial-gradient(ellipse 70% 90% at 5%  60%, rgba(74,144,226,0.14) 0%, transparent 60%),
    radial-gradient(ellipse 55% 65% at 92% 22%, rgba(230,57,70,0.11)  0%, transparent 60%),
    radial-gradient(ellipse 45% 55% at 55% 95%, rgba(39,201,122,0.08) 0%, transparent 50%),
    radial-gradient(ellipse 30% 40% at 70% 50%, rgba(74,144,226,0.05) 0%, transparent 50%),
    linear-gradient(160deg, #090d1a 0%, #111827 60%, #111827 100%);
}
.hero-particles { position: absolute; inset: 0; pointer-events: none; z-index: 1; }
.p-dot {
  position: absolute; border-radius: 50%; opacity: 0.14;
  animation: pfloat var(--dur,10s) ease-in-out infinite;
  animation-delay: var(--del,0s);
}
@keyframes pfloat {
  0%,100% { transform: translate(0,0); }
  33%      { transform: translate(16px,-22px); }
  66%      { transform: translate(-12px,14px); }
}
.hero-content { position: relative; z-index: 2; max-width: 860px; padding: 72px 0; }

/* ── Large Logo in Hero ─────────────────────────────────────── */
.hero-logo-large {
  display: flex;
  align-items: center;
  gap: 22px;
  margin-bottom: 44px;
}
.hero-logo-large-text { display: flex; flex-direction: column; line-height: 1.15; }
.hll-main {
  font-family: 'Space Grotesk', sans-serif;
  font-weight: 700; font-size: 1.75rem;
  letter-spacing: 0.2em; color: var(--text);
}
.hll-sub {
  font-family: 'Space Grotesk', sans-serif;
  font-weight: 600; font-size: 1.05rem;
  letter-spacing: 0.26em; color: var(--green);
  text-transform: uppercase;
}

/* ── Hero wordmark (text-only, no logo) ─────────────────────── */
.hero-wordmark {
  display: flex;
  flex-direction: column;
  align-items: flex-start;
  gap: 0;
  margin-bottom: 22px;
}
.hwm-main {
  font-family: 'Space Grotesk', sans-serif;
  font-weight: 700;
  font-size: 1.6rem;
  letter-spacing: 0.22em;
  color: var(--text);
  line-height: 1.1;
}
.hwm-sub {
  font-family: 'Space Grotesk', sans-serif;
  font-weight: 500;
  font-size: 0.95rem;
  letter-spacing: 0.28em;
  color: var(--green);
  text-transform: uppercase;
  margin-top: 2px;
}
.hwm-presents {
  font-family: 'Space Grotesk', sans-serif;
  font-weight: 600;
  font-size: 0.72rem;
  letter-spacing: 0.22em;
  text-transform: uppercase;
  color: #e63946;
  margin-top: 22px;
}

/* ── TBDS Acronym ───────────────────────────────────────────── */
.tbds-acronym {
  font-family: 'Space Grotesk', sans-serif;
  font-size: clamp(3.5rem, 9vw, 6.3rem);
  font-weight: 700;
  letter-spacing: 0.12em;
  line-height: 1;
  background: linear-gradient(135deg, #4a90e2 0%, #5eb8e8 40%, #27c97a 100%);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
  display: inline-block;
  margin-bottom: 4px;
  filter: drop-shadow(0 0 40px rgba(74,144,226,0.3));
}
.hero-tandem {
  font-family: 'Space Grotesk', sans-serif;
  font-size: clamp(1.2rem, 2.5vw, 1.8rem);
  font-weight: 400;
  color: var(--text-dim);
  letter-spacing: 0.02em;
  margin-bottom: 6px;
}
.hero-subtitle {
  font-size: 1.15rem;
  color: var(--text-dim);
  font-style: italic;
  margin-bottom: 36px;
}
.hero-badges { display: flex; flex-wrap: wrap; gap: 10px; margin-bottom: 48px; }
.hero-badge {
  display: flex; align-items: stretch;
  background: rgba(255,255,255,0.04);
  border: 1px solid var(--border-med);
  border-radius: 5px; overflow: hidden;
  transition: border-color var(--trans), transform var(--trans), background var(--trans);
}
.hero-badge:hover { border-color: rgba(255,255,255,0.25); transform: translateY(-2px); background: rgba(255,255,255,0.07); }
.hero-badge-accent { width: 4px; flex-shrink: 0; }
.hero-badge span { padding: 10px 18px; font-size: 0.88rem; font-weight: 600; color: var(--text); display: flex; align-items: center; }
.hero-ctas { display: flex; gap: 14px; flex-wrap: wrap; }

/* ══════════════════════════════════════════════════════════════
   BUTTONS
══════════════════════════════════════════════════════════════ */
.btn {
  display: inline-flex; align-items: center; gap: 8px;
  padding: 14px 30px; border-radius: 5px;
  font-size: 0.95rem; font-weight: 600;
  font-family: 'Space Grotesk', sans-serif;
  letter-spacing: 0.02em;
  transition: all var(--trans); cursor: pointer; border: none;
}
.btn-blue  { background: var(--blue); color: #fff; }
.btn-blue:hover  { background: #3a7fce; transform: translateY(-2px); box-shadow: 0 12px 32px rgba(74,144,226,0.4); }
.btn-red   { background: var(--red); color: #fff; }
.btn-red:hover   { background: #c8303c; transform: translateY(-2px); box-shadow: 0 12px 32px rgba(230,57,70,0.4); }
.btn-green { background: var(--green); color: #0d1220; }
.btn-green:hover { background: #20b86d; transform: translateY(-2px); box-shadow: 0 12px 32px rgba(39,201,122,0.35); }
.btn-outline { background: transparent; color: var(--text); border: 1.5px solid rgba(255,255,255,0.2); }
.btn-outline:hover { background: rgba(255,255,255,0.05); border-color: rgba(255,255,255,0.4); transform: translateY(-2px); }
.btn-sm { padding: 10px 22px; font-size: 0.86rem; }

/* ══════════════════════════════════════════════════════════════
   SECTION HEADER BARS  (PPT style)
══════════════════════════════════════════════════════════════ */
.sh {
  width: 100%; background: var(--bg-strip);
  position: relative; padding: 18px 0; margin-bottom: 56px;
}
.sh::before {
  content: ''; position: absolute;
  top: 0; left: 0; right: 0; height: 3px;
}
.sh-inner {
  display: block; max-width: var(--max-w);
  margin: 0 auto; padding: 0 32px;
  font-family: 'Space Grotesk', sans-serif;
  font-size: 0.78rem; font-weight: 700;
  letter-spacing: 0.28em; text-transform: uppercase;
}
.sh-sub {
  display: block; max-width: var(--max-w);
  margin: 9px auto 0; padding: 0 32px;
  font-size: 1rem; color: var(--text-dim);
  font-family: 'Inter', sans-serif; font-weight: 400;
  letter-spacing: 0; text-transform: none;
}
.sh-red::before     { background: var(--red); }
.sh-red .sh-inner   { color: var(--red); }
.sh-blue::before    { background: var(--blue); }
.sh-blue .sh-inner  { color: var(--blue); }
.sh-green::before   { background: var(--green); }
.sh-green .sh-inner { color: var(--green); }
.sh-amber::before   { background: var(--amber); }
.sh-amber .sh-inner { color: var(--amber); }

/* ══════════════════════════════════════════════════════════════
   STATS GRID
══════════════════════════════════════════════════════════════ */
.stats-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 20px; }
.stat-card {
  background: var(--bg-card); border-radius: var(--r);
  padding: 36px 32px; position: relative; overflow: hidden;
  transition: transform var(--trans), box-shadow var(--trans);
  border: 1px solid var(--border);
}
.stat-card::before { content: ''; position: absolute; top: 0; left: 0; right: 0; height: 3px; }
.stat-card:hover   { transform: translateY(-5px); box-shadow: 0 24px 56px rgba(0,0,0,0.5); }
.sc-red::before  { background: var(--red); }
.sc-red:hover    { box-shadow: 0 24px 56px rgba(230,57,70,0.2); border-color: rgba(230,57,70,0.25); }
.sc-blue::before { background: var(--blue); }
.sc-blue:hover   { box-shadow: 0 24px 56px rgba(74,144,226,0.2); border-color: rgba(74,144,226,0.25); }
.sc-amber::before{ background: var(--amber); }
.sc-amber:hover  { box-shadow: 0 24px 56px rgba(245,166,35,0.2); border-color: rgba(245,166,35,0.25); }
.stat-num {
  font-family: 'Space Grotesk', sans-serif;
  font-size: clamp(3rem, 6vw, 4.5rem);
  font-weight: 700; line-height: 1;
  margin-bottom: 12px; letter-spacing: -0.02em;
}
.sc-red   .stat-num { color: var(--red); }
.sc-blue  .stat-num { color: var(--blue); }
.sc-amber .stat-num { color: var(--amber); }
.stat-label { font-weight: 700; font-size: 1rem; margin-bottom: 12px; color: var(--text); }
.stat-rule  { width: 40px; height: 1px; background: var(--border-med); margin-bottom: 12px; }
.stat-desc  { font-size: 0.92rem; color: var(--text-dim); line-height: 1.6; }

/* ══════════════════════════════════════════════════════════════
   TWO-COL LAYOUTS
══════════════════════════════════════════════════════════════ */
.two-col    { display: grid; grid-template-columns: 1fr 1fr; gap: 44px; align-items: start; }
.two-col-lg { display: grid; grid-template-columns: 1.1fr 0.9fr; gap: 52px; align-items: start; }
.section-title { font-size: clamp(1.6rem, 3.2vw, 2.2rem); font-weight: 700; margin-bottom: 20px; color: var(--text); }
.section-body  { font-size: 1.02rem; color: var(--text-dim); line-height: 1.75; margin-bottom: 28px; }
.feature-list  { display: flex; flex-direction: column; gap: 16px; }
.feature-item  { display: flex; align-items: flex-start; gap: 13px; font-size: 0.97rem; color: var(--text); line-height: 1.6; }
.feature-dot   { width: 14px; height: 14px; border-radius: 3px; flex-shrink: 0; margin-top: 4px; }

/* ══════════════════════════════════════════════════════════════
   COMPARISON TABLE
══════════════════════════════════════════════════════════════ */
.compare-wrap { background: var(--bg-card); border-radius: var(--r); overflow: hidden; border: 1px solid var(--border); }
.compare-table { width: 100%; border-collapse: collapse; font-size: 0.92rem; }
.compare-table thead th { padding: 15px 22px; font-family: 'Space Grotesk', sans-serif; font-weight: 700; font-size: 0.88rem; text-align: center; }
.compare-table thead th:first-child { background: transparent; width: 115px; }
.compare-table thead th.th-tbds  { background: var(--red); color: #fff; }
.compare-table thead th.th-chemo { background: transparent; color: var(--text-dim); font-size: 0.82rem; }
.compare-table tbody tr { border-top: 1px solid var(--border); transition: background var(--trans); }
.compare-table tbody tr:hover { background: rgba(255,255,255,0.03); }
.compare-table td  { padding: 14px 22px; vertical-align: middle; }
.td-label { color: var(--text-dim); font-size: 0.85rem; font-weight: 600; }
.td-check { color: var(--green); font-size: 0.9rem; line-height: 1.6; }
.td-cross { color: var(--text-muted); font-size: 0.9rem; line-height: 1.6; }

/* ══════════════════════════════════════════════════════════════
   CONSTRUCT CARDS
══════════════════════════════════════════════════════════════ */
.construct-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 18px; }
.construct-card {
  background: var(--bg-card); border-radius: var(--r);
  padding: 30px 24px; position: relative; overflow: hidden;
  border: 1px solid var(--border);
  transition: all var(--trans); cursor: default;
}
.construct-card::before {
  content: ''; position: absolute;
  top: 0; left: 0; right: 0; height: 4px;
  transition: height var(--trans);
}
.construct-card:hover { transform: translateY(-6px); }
.construct-card:hover::before { height: 6px; }
.cc-ps14::before   { background: var(--blue); }
.cc-ps141::before  { background: var(--red); }
.cc-isb21::before  { background: var(--green); }
.cc-isb22::before  { background: var(--amber); }
.cc-ps14:hover   { box-shadow: 0 28px 60px rgba(74,144,226,0.2);  border-color: rgba(74,144,226,0.25); }
.cc-ps141:hover  { box-shadow: 0 28px 60px rgba(230,57,70,0.2);   border-color: rgba(230,57,70,0.25); }
.cc-isb21:hover  { box-shadow: 0 28px 60px rgba(39,201,122,0.2);  border-color: rgba(39,201,122,0.25); }
.cc-isb22:hover  { box-shadow: 0 28px 60px rgba(245,166,35,0.2);  border-color: rgba(245,166,35,0.25); }
.construct-name { font-family: 'Space Grotesk', sans-serif; font-size: 1.75rem; font-weight: 700; margin-bottom: 4px; letter-spacing: -0.01em; }
.cc-ps14  .construct-name { color: var(--blue); }
.cc-ps141 .construct-name { color: var(--red); }
.cc-isb21 .construct-name { color: var(--green); }
.cc-isb22 .construct-name { color: var(--amber); }
.construct-role  { font-size: 0.85rem; font-weight: 700; color: var(--text); margin-bottom: 20px; }
.construct-specs { padding: 13px 0; border-top: 1px solid var(--border); border-bottom: 1px solid var(--border); margin-bottom: 20px; display: flex; flex-direction: column; gap: 6px; }
.construct-spec  { font-family: 'JetBrains Mono', monospace; font-size: 0.82rem; color: var(--text-dim); }
.construct-points { display: flex; flex-direction: column; gap: 10px; margin-bottom: 24px; }
.construct-point { font-size: 0.9rem; color: var(--text-dim); padding-left: 16px; position: relative; line-height: 1.5; }
.construct-point::before { content: '·'; position: absolute; left: 0; color: var(--text-muted); }
.construct-badge { display: inline-block; padding: 7px 20px; border-radius: 4px; font-size: 0.78rem; font-weight: 700; font-family: 'Space Grotesk', sans-serif; letter-spacing: 0.06em; color: #fff; }
.cc-ps14  .construct-badge { background: var(--blue); }
.cc-ps141 .construct-badge { background: var(--red); }
.cc-isb21 .construct-badge { background: var(--green); color: #0d1220; }
.cc-isb22 .construct-badge { background: var(--amber); color: #0d1220; }

/* ══════════════════════════════════════════════════════════════
   MoA STEP CARDS
══════════════════════════════════════════════════════════════ */
.moa-grid {
  display: grid; grid-template-columns: repeat(4, 1fr);
  background: var(--bg-card); border-radius: var(--r);
  overflow: hidden; border: 1px solid var(--border);
}
.moa-card { padding: 36px 26px; border-right: 1px solid var(--border); position: relative; }
.moa-card:last-child { border-right: none; }
.moa-card::before { content: ''; position: absolute; top: 0; left: 0; right: 0; height: 4px; }
.moa-01::before { background: var(--blue); }
.moa-02::before { background: var(--amber); }
.moa-03::before { background: var(--red); }
.moa-04::before { background: var(--green); }
.moa-num { font-family: 'Space Grotesk', sans-serif; font-size: 3.2rem; font-weight: 700; line-height: 1; margin-bottom: 22px; letter-spacing: -0.02em; }
.moa-01 .moa-num { color: var(--blue); }
.moa-02 .moa-num { color: var(--amber); }
.moa-03 .moa-num { color: var(--red); }
.moa-04 .moa-num { color: var(--green); }
.moa-title { font-family: 'Space Grotesk', sans-serif; font-size: 1.05rem; font-weight: 700; color: var(--text); margin-bottom: 14px; }
.moa-desc  { font-size: 0.92rem; color: var(--text-dim); line-height: 1.65; }
.moa-footnote {
  background: var(--bg-card2); border-top: 1px solid var(--border);
  padding: 16px 26px; font-size: 0.88rem; color: var(--text-dim);
  font-style: italic; text-align: center; border-radius: 0 0 var(--r) var(--r);
}

/* ══════════════════════════════════════════════════════════════
   IC50 DISPLAY
══════════════════════════════════════════════════════════════ */
.ic50-stack { display: flex; flex-direction: column; gap: 14px; }
.ic50-card { background: var(--bg-card); border-radius: var(--r); padding: 22px 26px; border: 1.5px solid; transition: transform var(--trans); }
.ic50-card:hover { transform: translateY(-2px); }
.ic50-card.ic-red   { border-color: var(--red); }
.ic50-card.ic-blue  { border-color: var(--blue); }
.ic50-card.ic-green { border-color: rgba(39,201,122,0.4); border-style: dashed; }
.ic50-label { font-family: 'JetBrains Mono', monospace; font-size: 0.82rem; color: var(--text-dim); margin-bottom: 10px; }
.ic50-value { font-family: 'Space Grotesk', sans-serif; font-size: 2.3rem; font-weight: 700; display: flex; align-items: baseline; gap: 16px; line-height: 1.1; }
.ic-red   .ic50-value { color: var(--red); }
.ic-blue  .ic50-value { color: var(--blue); }
.ic-green .ic50-value { color: var(--green); }
.ic50-endpoint { font-size: 0.8rem; color: var(--text-muted); font-style: italic; font-family: 'Inter', sans-serif; }
.ic50-note { margin-top: 10px; font-size: 0.88rem; color: var(--text-dim); }
.ic50-zero-bar {
  margin-top: 14px; background: var(--bg-card2);
  border: 1px solid rgba(39,201,122,0.35); border-radius: 5px;
  padding: 13px 18px; font-size: 0.9rem; color: var(--green);
  font-weight: 600; display: flex; align-items: center; gap: 10px;
}

/* ══════════════════════════════════════════════════════════════
   STUDY PANELS
══════════════════════════════════════════════════════════════ */
.study-panel { background: var(--bg-card); border-radius: var(--r); overflow: hidden; border: 1px solid var(--border); }
.study-panel-head { padding: 20px 26px; font-family: 'Space Grotesk', sans-serif; font-size: 1rem; font-weight: 700; border-bottom: 1px solid var(--border); }
.study-row { display: flex; align-items: stretch; border-bottom: 1px solid var(--border); transition: background var(--trans); }
.study-row:last-child { border-bottom: none; }
.study-row:hover { background: rgba(255,255,255,0.025); }
.study-row-bar { width: 4px; flex-shrink: 0; }
.study-row-body { padding: 14px 20px; }
.study-row-name { font-size: 0.9rem; font-weight: 600; color: var(--text); margin-bottom: 4px; }
.study-row-desc { font-size: 0.84rem; color: var(--text-dim); line-height: 1.55; }
.study-assay { padding: 11px 20px; font-size: 0.8rem; color: var(--text-muted); font-style: italic; background: rgba(0,0,0,0.2); }

/* ══════════════════════════════════════════════════════════════
   IN-VIVO CARDS
══════════════════════════════════════════════════════════════ */
.invivo-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 26px; }
.invivo-card { background: var(--bg-card); border-radius: var(--r); overflow: hidden; border: 1px solid var(--border); }
.invivo-card-head { padding: 22px 26px; border-bottom: 1px solid var(--border); }
.invivo-card-title { font-family: 'Space Grotesk', sans-serif; font-size: 1.3rem; font-weight: 700; color: var(--red); margin-bottom: 5px; }
.invivo-card-sub { font-size: 0.88rem; color: var(--text-dim); }
.treatment-row { display: flex; align-items: stretch; border-bottom: 1px solid var(--border); transition: background var(--trans); }
.treatment-row:last-child { border-bottom: none; }
.treatment-row:hover { background: rgba(255,255,255,0.025); }
.treatment-bar { width: 4px; flex-shrink: 0; }
.treatment-body { padding: 13px 20px; }
.treatment-name { font-size: 0.9rem; font-weight: 600; margin-bottom: 4px; }
.treatment-desc { font-size: 0.84rem; color: var(--text-dim); }

/* ── Prostate 4-col ─────────────────────────────────────────── */
.prostate-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 18px; }
.prostate-card {
  background: var(--bg-card); border-radius: var(--r);
  padding: 26px 22px; position: relative;
  border: 1px solid var(--border);
  transition: transform var(--trans), box-shadow var(--trans);
}
.prostate-card:hover { transform: translateY(-3px); box-shadow: 0 18px 44px rgba(0,0,0,0.35); }
.prostate-card::before { content: ''; position: absolute; top: 0; left: 0; right: 0; height: 4px; border-radius: var(--r) var(--r) 0 0; }
.pc-gray::before  { background: var(--gray); }
.pc-green::before { background: var(--green); }
.pc-doc::before   { background: var(--amber); }
.prostate-title { font-family: 'Space Grotesk', sans-serif; font-size: 1.05rem; font-weight: 700; margin-bottom: 4px; }
.pc-gray  .prostate-title { color: var(--text-dim); }
.pc-green .prostate-title { color: var(--green); }
.pc-doc   .prostate-title { color: var(--amber); }
.prostate-dose { font-size: 0.85rem; color: var(--text-dim); margin-bottom: 14px; }
.prostate-badge { display: inline-block; padding: 5px 14px; border-radius: 4px; font-size: 0.76rem; font-weight: 700; font-family: 'Space Grotesk', sans-serif; letter-spacing: 0.05em; margin-bottom: 14px; }
.pc-gray  .prostate-badge { background: var(--bg-card2); color: var(--text-dim); }
.pc-green .prostate-badge { background: var(--green); color: #0d1220; }
.pc-doc   .prostate-badge { background: var(--amber); color: #0d1220; }
.prostate-body    { font-size: 0.88rem; color: var(--text-dim); line-height: 1.65; margin-bottom: 12px; }
.prostate-insight { font-size: 0.82rem; color: var(--text-muted); font-style: italic; padding: 9px 13px; background: rgba(0,0,0,0.2); border-radius: 4px; border-left: 2px solid var(--border-med); }
.pc-green .prostate-insight { border-left-color: var(--green); color: rgba(39,201,122,0.85); }
.pc-doc   .prostate-insight { border-left-color: var(--amber); color: rgba(245,166,35,0.85); }

/* ── ISB-22 ─────────────────────────────────────────────────── */
.isb22-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 44px; align-items: start; }
.isb22-specs { display: flex; flex-direction: column; border: 1px solid var(--border); border-radius: var(--r); overflow: hidden; }
.isb22-row { display: flex; border-bottom: 1px solid var(--border); }
.isb22-row:last-child { border-bottom: none; }
.isb22-key { padding: 14px 20px; background: var(--bg-card2); font-size: 0.8rem; font-weight: 700; color: var(--amber); width: 120px; flex-shrink: 0; font-family: 'Space Grotesk', sans-serif; letter-spacing: 0.06em; text-transform: uppercase; display: flex; align-items: center; }
.isb22-val { padding: 14px 20px; background: var(--bg-card); font-size: 0.9rem; color: var(--text-dim); flex: 1; display: flex; align-items: center; }
.indication-cards { display: flex; flex-direction: column; gap: 14px; }
.indication-card { background: var(--bg-card); border-radius: var(--r); overflow: hidden; border: 1px solid var(--border); transition: border-color var(--trans), transform var(--trans); }
.indication-card:hover { border-color: var(--border-med); transform: translateX(5px); }
.indication-card-head { padding: 13px 20px; display: flex; align-items: center; gap: 13px; border-bottom: 1px solid var(--border); }
.indication-card-bar  { width: 4px; height: 22px; border-radius: 2px; flex-shrink: 0; }
.indication-name { font-size: 0.94rem; font-weight: 700; color: var(--text); }
.indication-vol  { font-size: 0.8rem; color: var(--text-dim); margin-left: auto; font-family: 'JetBrains Mono', monospace; }
.indication-body { padding: 11px 20px; font-size: 0.86rem; color: var(--text-dim); line-height: 1.6; }

/* ── Indication Matrix ──────────────────────────────────────── */
.indication-table { width: 100%; border-collapse: collapse; font-size: 0.92rem; }
.indication-table th { padding: 13px 20px; background: var(--red); color: #fff; font-family: 'Space Grotesk', sans-serif; font-size: 0.76rem; font-weight: 700; text-transform: uppercase; letter-spacing: 0.12em; text-align: center; }
.indication-table th:first-child { text-align: left; width: 190px; }
.indication-table th:last-child  { text-align: left; }
.indication-table td { padding: 15px 20px; border-bottom: 1px solid var(--border); text-align: center; vertical-align: middle; color: var(--text-dim); font-size: 0.9rem; }
.indication-table td:first-child { text-align: left; font-weight: 600; color: var(--text); }
.indication-table td:last-child  { text-align: left; font-size: 0.86rem; }
.indication-table tr:hover td    { background: rgba(255,255,255,0.025); }
.ind-check { color: var(--green); font-size: 1.1rem; font-weight: 700; }
.ind-dot   { color: var(--blue); font-size: 1.4rem; font-weight: 700; line-height: 1; }
.ind-dash  { color: var(--text-muted); }
.table-footnote { margin-top: 16px; font-size: 0.82rem; color: var(--text-muted); font-style: italic; }

/* ══════════════════════════════════════════════════════════════
   PAGE SUB-HERO
══════════════════════════════════════════════════════════════ */
.page-hero {
  padding: calc(var(--nav-h) + 52px) 0 52px;
  background: linear-gradient(160deg, #090d1a 0%, var(--bg-base) 100%);
  border-bottom: 1px solid var(--border);
}
.page-hero h1 { font-size: clamp(2rem, 4.5vw, 3.2rem); margin-bottom: 14px; }
.page-hero p  { font-size: 1.1rem; color: var(--text-dim); max-width: 640px; line-height: 1.7; }

/* ══════════════════════════════════════════════════════════════
   CTA BANNER
══════════════════════════════════════════════════════════════ */
.cta-section {
  background: var(--bg-surface);
  padding: 96px 0;
  border-top: 1px solid var(--border);
  text-align: center;
  position: relative;
  overflow: hidden;
}
.cta-section::before {
  content: '';
  position: absolute; inset: 0;
  background: radial-gradient(ellipse 60% 80% at 50% 50%, rgba(74,144,226,0.07) 0%, transparent 70%);
  pointer-events: none;
}
.cta-section h2 { font-size: clamp(1.8rem, 4vw, 2.8rem); margin-bottom: 16px; }
.cta-section p  { font-size: 1.05rem; color: var(--text-dim); margin-bottom: 40px; max-width: 600px; margin-left: auto; margin-right: auto; line-height: 1.7; }
.cta-btns { display: flex; gap: 16px; justify-content: center; flex-wrap: wrap; position: relative; }

/* ══════════════════════════════════════════════════════════════
   OPPORTUNITY PAGE SPECIFIC
══════════════════════════════════════════════════════════════ */
.opportunity-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 20px; }
.opp-card {
  background: var(--bg-card); border-radius: var(--r);
  padding: 32px 28px; border: 1px solid var(--border);
  position: relative; overflow: hidden;
  transition: all var(--trans);
}
.opp-card::before { content: ''; position: absolute; top: 0; left: 0; right: 0; height: 4px; }
.opp-card:hover { transform: translateY(-5px); }
.opp-card.oc-red::before    { background: var(--red); }
.opp-card.oc-red:hover      { box-shadow: 0 24px 56px rgba(230,57,70,0.18); border-color: rgba(230,57,70,0.2); }
.opp-card.oc-blue::before   { background: var(--blue); }
.opp-card.oc-blue:hover     { box-shadow: 0 24px 56px rgba(74,144,226,0.18); border-color: rgba(74,144,226,0.2); }
.opp-card.oc-green::before  { background: var(--green); }
.opp-card.oc-green:hover    { box-shadow: 0 24px 56px rgba(39,201,122,0.18); border-color: rgba(39,201,122,0.2); }
.opp-card.oc-amber::before  { background: var(--amber); }
.opp-card.oc-amber:hover    { box-shadow: 0 24px 56px rgba(245,166,35,0.18); border-color: rgba(245,166,35,0.2); }
.opp-icon { font-size: 2rem; margin-bottom: 18px; display:flex; align-items:center; }
.opp-icon svg { color: currentColor; opacity: 0.85; }
.opp-card h3 { font-size: 1.15rem; font-weight: 700; margin-bottom: 12px; }
.opp-card p  { font-size: 0.92rem; color: var(--text-dim); line-height: 1.7; }

.milestone-track { display: flex; flex-direction: column; gap: 0; }
.milestone-item {
  display: flex; align-items: flex-start; gap: 24px;
  padding: 28px 0; border-bottom: 1px solid var(--border);
  position: relative;
}
.milestone-item:last-child { border-bottom: none; }
.milestone-dot-col { display: flex; flex-direction: column; align-items: center; gap: 0; flex-shrink: 0; }
.milestone-dot {
  width: 16px; height: 16px; border-radius: 50%;
  border: 2px solid; flex-shrink: 0;
}
.milestone-dot.done    { background: var(--green); border-color: var(--green); box-shadow: 0 0 12px rgba(39,201,122,0.5); }
.milestone-dot.current { background: var(--blue);  border-color: var(--blue);  box-shadow: 0 0 12px rgba(74,144,226,0.5); animation: mblink 2s ease-in-out infinite; }
.milestone-dot.future  { background: transparent;  border-color: var(--text-muted); }
@keyframes mblink { 0%,100%{box-shadow:0 0 8px rgba(74,144,226,0.4)} 50%{box-shadow:0 0 20px rgba(74,144,226,0.8)} }
.milestone-line { width: 2px; flex: 1; background: var(--border); min-height: 20px; }
.milestone-body { padding-top: 0; }
.milestone-stage { font-size: 0.76rem; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; margin-bottom: 6px; }
.milestone-stage.done    { color: var(--green); }
.milestone-stage.current { color: var(--blue); }
.milestone-stage.future  { color: var(--text-muted); }
.milestone-title { font-family: 'Space Grotesk', sans-serif; font-size: 1.05rem; font-weight: 700; margin-bottom: 8px; }
.milestone-desc  { font-size: 0.9rem; color: var(--text-dim); line-height: 1.65; }

.competitive-table { width: 100%; border-collapse: collapse; font-size: 0.92rem; }
.competitive-table th { padding: 13px 20px; background: var(--bg-card2); color: var(--text-dim); font-family: 'Space Grotesk', sans-serif; font-size: 0.76rem; font-weight: 700; text-transform: uppercase; letter-spacing: 0.1em; text-align: center; border-bottom: 2px solid var(--border); }
.competitive-table th:first-child  { text-align: left; }
.competitive-table th.col-tbds { background: rgba(74,144,226,0.12); color: var(--blue); border-bottom-color: var(--blue); }
.competitive-table td { padding: 14px 20px; border-bottom: 1px solid var(--border); text-align: center; vertical-align: middle; color: var(--text-dim); }
.competitive-table td:first-child { text-align: left; font-weight: 600; color: var(--text); }
.competitive-table tr:hover td { background: rgba(255,255,255,0.025); }
.comp-yes   { color: var(--green); font-weight: 700; font-size: 1rem; }
.comp-no    { color: var(--text-muted); }
.comp-part  { color: var(--amber); }
.comp-tbds-cell { color: var(--blue); font-weight: 600; }

/* ══════════════════════════════════════════════════════════════
   CONTACT / FORMS
══════════════════════════════════════════════════════════════ */
.tab-bar { display: flex; border-bottom: 1px solid var(--border); margin-bottom: 36px; overflow-x: auto; }
.tab-btn { padding: 13px 24px; background: none; border: none; cursor: pointer; font-size: 0.92rem; font-weight: 500; color: var(--text-dim); border-bottom: 2px solid transparent; margin-bottom: -1px; transition: all var(--trans); font-family: 'Inter', sans-serif; white-space: nowrap; }
.tab-btn:hover { color: var(--text); }
.tab-btn.active { color: var(--text); border-bottom-color: var(--red); }
.tab-panel { display: none; }
.tab-panel.active { display: block; }
.form-group { margin-bottom: 22px; }
.form-label { display: block; font-size: 0.78rem; font-weight: 600; color: var(--text-dim); margin-bottom: 8px; letter-spacing: 0.08em; text-transform: uppercase; }
.form-input, .form-select, .form-textarea { width: 100%; background: var(--bg-card); border: 1px solid var(--border); border-radius: 5px; padding: 13px 16px; color: var(--text); font-size: 0.95rem; font-family: 'Inter', sans-serif; transition: border-color var(--trans), box-shadow var(--trans); outline: none; -webkit-appearance: none; }
.form-input:focus, .form-select:focus, .form-textarea:focus { border-color: var(--blue); box-shadow: 0 0 0 3px rgba(74,144,226,0.14); }
.form-textarea { resize: vertical; min-height: 120px; }
.form-select   { cursor: pointer; }
.form-select option { background: #1a2236; color: var(--text); }
.form-row  { display: grid; grid-template-columns: 1fr 1fr; gap: 18px; }
.form-note { font-size: 0.82rem; color: var(--text-muted); margin-top: 7px; }
.success-banner { display: none; background: var(--bg-card); border: 1px solid rgba(39,201,122,0.35); border-radius: var(--r); padding: 20px 24px; color: var(--green); font-weight: 600; font-size: 0.95rem; margin-top: 18px; align-items: center; gap: 12px; }
.success-banner.visible { display: flex; }

/* ══════════════════════════════════════════════════════════════
   INFO CARD  (generic)
══════════════════════════════════════════════════════════════ */
.info-card { background: var(--bg-card); border-radius: var(--r); padding: 30px; border: 1px solid var(--border); transition: all var(--trans); }
.info-card:hover { border-color: var(--border-med); transform: translateY(-3px); box-shadow: 0 18px 44px rgba(0,0,0,0.3); }
.info-card h3 { font-size: 1.05rem; font-weight: 700; margin-bottom: 14px; }

/* ══════════════════════════════════════════════════════════════
   FOOTER
══════════════════════════════════════════════════════════════ */
.footer { background: var(--bg-strip); border-top: 1px solid var(--border); padding: 60px 0 32px; }
.footer-grid { display: grid; grid-template-columns: 1.5fr 1fr 1fr; gap: 52px; margin-bottom: 44px; }
.footer-brand p { font-size: 0.9rem; color: var(--text-dim); margin-top: 18px; line-height: 1.7; max-width: 295px; }
.footer-col h4  { font-family: 'Space Grotesk', sans-serif; font-size: 0.74rem; font-weight: 700; letter-spacing: 0.18em; text-transform: uppercase; color: var(--text-dim); margin-bottom: 20px; }
.footer-col ul  { display: flex; flex-direction: column; gap: 12px; }
.footer-col a   { font-size: 0.92rem; color: var(--text-dim); transition: color var(--trans); }
.footer-col a:hover { color: var(--text); }
.footer-bottom { padding-top: 28px; border-top: 1px solid var(--border); display: flex; align-items: center; justify-content: space-between; font-size: 0.82rem; color: var(--text-muted); }
.footer-badge { display: flex; align-items: center; gap: 7px; font-size: 0.76rem; color: var(--text-muted); }
.footer-badge-dot { width: 7px; height: 7px; background: var(--green); border-radius: 50%; animation: bpulse 2.5s ease-in-out infinite; }
@keyframes bpulse { 0%,100% { opacity:1; } 50% { opacity:0.25; } }

/* ══════════════════════════════════════════════════════════════
   SCROLL REVEAL
══════════════════════════════════════════════════════════════ */
.reveal { opacity: 0; transform: translateY(24px); transition: opacity 0.7s ease, transform 0.7s ease; }
.reveal.delay-1 { transition-delay: 0.1s; }
.reveal.delay-2 { transition-delay: 0.2s; }
.reveal.delay-3 { transition-delay: 0.3s; }
.reveal.delay-4 { transition-delay: 0.4s; }
.reveal.visible { opacity: 1; transform: none; }

/* ══════════════════════════════════════════════════════════════
   RESPONSIVE
══════════════════════════════════════════════════════════════ */
@media (max-width: 1024px) {
  .construct-grid      { grid-template-columns: repeat(2,1fr); }
  .moa-grid            { grid-template-columns: repeat(2,1fr); }
  .moa-card            { border-right: none; border-bottom: 1px solid var(--border); }
  .moa-card:last-child { border-bottom: none; }
  .prostate-grid       { grid-template-columns: repeat(2,1fr); }
  .two-col-lg          { grid-template-columns: 1fr; }
  .isb22-grid          { grid-template-columns: 1fr; }
  .opportunity-grid    { grid-template-columns: repeat(2,1fr); }
}
@media (max-width: 768px) {
  html { font-size: 16px; }
  .container { padding: 0 20px; }
  .section        { padding: 60px 0; }
  .section--tight { padding: 44px 0; }
  .stats-grid  { grid-template-columns: 1fr; }
  .two-col     { grid-template-columns: 1fr; }
  .invivo-grid { grid-template-columns: 1fr; }
  .construct-grid  { grid-template-columns: 1fr; }
  .prostate-grid   { grid-template-columns: 1fr; }
  .footer-grid     { grid-template-columns: 1fr; gap: 36px; }
  .form-row        { grid-template-columns: 1fr; }
  .footer-bottom   { flex-direction: column; gap: 14px; text-align: center; }
  .opportunity-grid { grid-template-columns: 1fr; }
  .nav-links  { display: none; }
  .nav-toggle { display: flex; }
  body.nav-open .nav-links { display: flex; flex-direction: column; position: fixed; top: var(--nav-h); left: 0; right: 0; background: rgba(10,14,26,0.98); backdrop-filter: blur(20px); padding: 24px 32px; gap: 6px; border-bottom: 1px solid var(--border); z-index: 99; }
  .hero h1, .tbds-acronym { font-size: clamp(2.8rem, 12.6vw, 4.2rem); }
  .hero-content { padding: 44px 0; }
  /* Wordmark sizing on mobile */
  .hwm-main { font-size: 1.35rem; }
  .hwm-sub  { font-size: 0.82rem; }
  /* CTA button groups — full-width stacking on very small screens */
  .cta-btns { gap: 12px; }
  .btn { padding: 13px 24px; font-size: 0.9rem; }
  /* MoA cards — single column on mobile to prevent clipping */
  .moa-grid { grid-template-columns: 1fr; }
  .moa-card { border-right: none; border-bottom: 1px solid var(--border); padding: 28px 22px; }
  .moa-card:last-child { border-bottom: none; }
  .moa-num  { font-size: 2.4rem; margin-bottom: 14px; }
}

/* ══════════════════════════════════════════════════════════════
   Pipeline Overview Chart
══════════════════════════════════════════════════════════════ */
.poc-wrap {
  background: var(--bg-card);
  border: 1px solid var(--border);
  border-radius: var(--r);
  overflow: hidden;
  margin-bottom: 16px;
}

/* Stage label header row */
.poc-label-row {
  display: flex;
  align-items: center;
  padding: 10px 24px;
  border-bottom: 1px solid var(--border);
  background: var(--bg-strip);
}
.poc-stage-labels {
  display: flex;
  width: 100%;
}
.poc-stage-labels span {
  flex: 1;
  text-align: center;
  font-size: 0.65rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
}

/* Data rows */
.poc-row {
  display: flex;
  align-items: center;
  padding: 18px 24px;
  border-bottom: 1px solid var(--border);
  gap: 0;
  transition: background var(--trans);
}
.poc-row:hover { background: rgba(255,255,255,0.02); }

.poc-cell-id {
  width: 160px;
  flex-shrink: 0;
  display: flex;
  flex-direction: column;
  gap: 3px;
}
.poc-name {
  font-family: 'Space Grotesk', sans-serif;
  font-size: 1.05rem;
  font-weight: 700;
  letter-spacing: 0.04em;
}
.poc-role {
  font-size: 0.72rem;
  color: var(--text-muted);
  font-weight: 500;
}

.poc-cell-ind {
  width: 200px;
  flex-shrink: 0;
  font-size: 0.82rem;
  color: var(--text-dim);
  padding-right: 20px;
}

.poc-cell-bar { flex: 1; }

/* Bar segments */
.poc-bar {
  display: flex;
  height: 34px;
  gap: 2px;
}
.poc-seg {
  flex: 1;
  border-radius: 3px;
  display: flex;
  align-items: center;
  justify-content: center;
  transition: opacity 0.2s;
}
.poc-seg-done {
  background: color-mix(in srgb, var(--bc) 28%, transparent);
  border: 1px solid color-mix(in srgb, var(--bc) 45%, transparent);
}
.poc-seg-active {
  background: var(--bc);
  box-shadow: 0 2px 12px color-mix(in srgb, var(--bc) 40%, transparent);
}
.poc-seg-active span {
  font-size: 0.62rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: #fff;
  white-space: nowrap;
}
.poc-seg-empty {
  background: rgba(255,255,255,0.04);
  border: 1px solid rgba(255,255,255,0.06);
}

/* Legend */
.poc-legend {
  display: flex;
  gap: 24px;
  justify-content: flex-end;
  padding: 4px 0 8px;
}
.poc-leg-item {
  display: flex;
  align-items: center;
  gap: 7px;
  font-size: 0.75rem;
  color: var(--text-muted);
}
.poc-leg-dot {
  width: 12px; height: 12px;
  border-radius: 2px;
  flex-shrink: 0;
}
.poc-leg-dot.poc-leg-active { background: var(--blue); }
.poc-leg-dot.poc-leg-done   { background: rgba(74,144,226,0.28); border: 1px solid rgba(74,144,226,0.45); }
.poc-leg-dot.poc-leg-empty  { background: rgba(255,255,255,0.04); border: 1px solid rgba(255,255,255,0.1); }

/* Mobile: stack cells */
@media (max-width: 768px) {
  .poc-label-row { display: none; }
  .poc-row { flex-direction: column; align-items: flex-start; gap: 10px; padding: 16px 18px; }
  .poc-cell-id { width: 100%; flex-direction: row; align-items: baseline; gap: 10px; }
  .poc-cell-ind { width: 100%; padding: 0; font-size: 0.8rem; }
  .poc-cell-bar { width: 100%; }
  .poc-seg-active span { font-size: 0.58rem; }
  .poc-legend { justify-content: flex-start; }
}